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oxidized and is a waste product The problem is, ammonium is rather toxic to most tissues (except the medullary interstitium) and the liver immediately converts it to urea (mostly) and a smaller, but a crucial, amount of glutamine (We will take up the fate of this glutamine in 9 on acid-base balance) Urea production proceeds continuously and constitutes about half of the normal solute content of urine The normal level in the blood is quite variable (3 mmol/L 9mmol/L),1 reflecting variations in both protein intake and renal handling of urea Over the long term (days to weeks), renal urea excretion must match hepatic production; otherwise, plasma levels would rise into the pathological range, producing a condition

1 Plasma urea concentration is usually expressed as blood urea nitrogen (BUN) in units of milligrams per deciliter Each molecule of urea contains 2 atoms of nitrogen, so 1 mmol of urea contains 2 mmol of nitrogen, with a combined weight of 28 mg Thus, the normal levels of plasma urea are expressed as BUN values ranging from 84 mg/dL to 252 mg/dL We use units of millimoles per liter because we can then directly convert to osmolality

2 10

Circuit capacity (56/64 kbit/s, 000s)

reNaL haNDLING OF OrGaNIC SUBStaNCeS / 73

2 10 19

Figure 8-1 Example of the decreasing importance of bandwidth constraints Source: ITU, adapted from FCC

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called uremia On a shorter term basis (hours to days), urea excretion rate may not exactly match production rate because urea excretion is also regulated for purposes other than keeping a stable plasma level As discussed in 6, urea is a key solute involved in regulating the excretion of water To summarize renal handling of urea, urea is freely filtered About half is reabsorbed in the proximal tubule An amount equal to that reabsorbed is then secreted back into the loop of Henle Finally, about half is reabsorbed again in the medullary collecting duct The net result is that about half the filtered load is excreted (Figure 5 3)

4 9 (D) 2 10 /27 19 (E) 2 10

110% 55

Addressing constraints: Increased trans-Atlantic bandwidth 10,000 100,000

16

100% 1

76 I (aq) + H+(aq) + MnO4 (aq) Mn2+(aq) + H2O(l) + I2(s) What is the coefficient of H+ when the above reaction is balanced (A) 12 (B) 32 (C) 16 (D) 8 (E) 2

50% 12

To advance the VoP cause, there should be less emphasis on standards development and more emphasis on delivering products that cut the equipment cost by 100 percent and the operations cost by 50 percent It is only at these levels that carriers can begin to consider alternatives to the present mode of operation (PMO) from a financial viability standpoint (for a simple replacement of an existing system with a new one that performs equally) Alternatively, a slew of new revenue-generating applications are needed You might be tempted to add toll quality as a mandatory requirement to the list of characteristics (given previously) that have to be taken into account However, considering the usual low quality of cellular telephony services, which people have gotten used to lately, quality is perhaps a negotiable parameter As noted in 1, the opportunities for VoP have to be in the telephone-to-telephone solution Only a small subset of people in the world can afford a $2,000 PC just to make and receive telephone calls, as illustrated in Figure 8-2 The perspective market is represented by the total

50% 25

80 If a current of 060 amperes is passed through the electrolytic cell for 075 hours, how should you 2 calculate the grams of S2O3 formed (A) (B) (C) (D) (E) (060)(075)(3600)(112) / (96500)(8) (060)(075)(3600)(112) / (96500)(10) (060)(075)(60)(32) / (96500)(8) (060)(075)(3600)(112) / (10) (060)(075)(32) / (96500)(8)

Figure 5 3 Urea handling by the kidney The arrows indicate the regions where transport occurs and the direction of transport The boxes show (in the top half) the percentage of the filtered load remaining in the tubule and, in the bottom half, the luminal concentration relative to the concentration in plasma The numbers are subject to considerable variability, particularly for regions beyond the proximal tubule, because they are so dependent on hydration status

Current market size Market growth projections Impact on telephony network usage Service access requirements

17

74 / 5

81 When 226 Ra decays, it emits 2 particles, then a 88 particle, followed by an particle The resulting nucleus is: (A) (B) (C) (D) (E)

100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0%

.

212 83 222 86 214 82 214 83 212 85

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