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The Cori Cycle Requires Net Energy Input More energy is required to generate glucose from lactate in the liver than is obtained by oxidizing glucose in red blood cells Glycolysis of glucose to lactate produces a net of two molecules of ATP per molecule of glucose oxidized By comparison, gluconeogenesis from lactate requires 6 ATP equivalents (4 ATP, 2 GTP) to produce one molecule of glucose The two-step sequence catalyzed by pyruvate carboxylase and pyruvate carboxykinase requires one ATP plus one GTP per molecule of pyruvate An additional ATP is required for the phosphoglycerate kinase-catalyzed conversion of 3-phosphglycerate to 1,3bisphosphoglycerate Since two molecules of lactate are utilized for the synthesis of each molecule of glucose, the total energy cost is 2 x 3 or 6, high-energy bonds Is the Cori Cycle Just a Waste of Energy It may appear that continued breakdown and resynthesis of glucose is wasteful.

(13.29)

74 75

Earning disparities between immigrants and native-born Canadians , Canadian Review of Sociology and Anthropology 37 (3): 289 311 Li, P, 2003 Destination Canada: Immigration Debates and Issues (Oxford University Press, Don Mills, ONT) Li, P, 2005 The rise and fall of Chinese immigration to Canada: newcomers from Hong Kong SAR of China and Mainland China, 1980 2000 , International Migration 43 (3): 9 32 Li, V, 1992 Why we invest in Canada , Dialogue (Asia-Pacific Foundation of Canada), 6 (1), p 3 Li, W, (ed) 2006 From Urban Enclave to Ethnic Suburb: New Asian Communities in Pacific Rim Countries (University of Hawaii Press, Honolulu) Li, W, Oberle, A and Dymski G, 2007 Global Banking and Financial Services to Immigrants in Canada and the United States (Centre for Research on Immigration and Integration in the Metropolis, Working Paper Series No 07-06, Vancouver) Lightman, E.

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It is, however, the small energy cost paid by the liver and renal cortex to permit effective functioning of other cells Since erythrocytes lack both mitochondria and a nucleus, they are smaller than most cells; their relatively small cell size permits easy passage of red cells through tiny capillaries but renders red blood cells completely dependent on glycolysis to lactate for their ATP The conversion of lactate to glucose occurs in the liver, where ample ATP can be generated from the P-oxidation of long-chain fatty acids Glycolysis to lactate is also advantageous during strenuous exercise Although the yield of ATP per glucose molecule metabolized is much lower than when glucose is oxidized all the way to CO2 and water, the rate at which ATP can be generated by glycolysis is greater than the rate at which ATP can be produced by oxidative phosphorylation.

DISABLE TRIGGER DDL_Create_Table_Sample ON DATABASE; ENABLE TRIGGER DDL_Create_Table_Sample ON DATABASE;

TABLE 2-4

and Irving, A, 1991 Restructuring Canada s welfare state , Journal of Social Policy 20: 65 86 Lin, G, 1997 Red Capitalism in South China: Growth and Development of the Pearl River Delta (UBC Press, Vancouver) Lo, L, 2006 Suburban housing and indoor shopping: The production of the contemporary Chinese landscape in Toronto , in W Li (ed), From Urban Enclave to Ethnic Suburb: New Asian Communities in Pacific Rim Countries (University of Hawaii Press, Honolulu), pp 134 54 Lo, L, Teixeira, C and Truelove, M, 2002 Cultural Resources, Ethnic Strategies and Immigrant Entrepreneurship: A Comparative Study of Five Groups in the Toronto CMA (Joint Centre of Excellence for Research on Immigration and Settlement, University of Toronto, Working Paper No 21) Lo, L and Wang, L, 2004.

Most of the lactate generated by muscle is secreted into the circulation and returned to the liver, where it is converted back into glucose by the process of gluconeogenesis The energy required to convert lactate into glucose is derived from the mitochondria1 P-oxidation of fatty acids and transfer of the reducing equivalents from NADH and FADH2 into the ATP-generating oxidative phosphorylation system of mitochondria..

The bull market in bonds that began in the early 1980s has largely run its course. The majority of possible profits has already been made. This does

This procedure assumes that Linux is already installed and working on the computer. If this is not the case, follow the instructions for adding a hard disk on your current operating system. Later, when you install Linux, you can identify this disk when you are asked to partition your hard disk(s).

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